Age-Specific Percentile-based Prostate-Specific Antigen Cutoff Values Predict the Risk of Prostate Cancer: a single hospital observation

Background Testing for prostate-specific antigen (PSA) is often recommended men with a potential risk of prostate cancer (PCa) before requiring advanced examination. However, the best PSA cutoff value remains controversial. Object We compared predictive performance age-specific percentile-based thresholds conventional >4 ng/mL PCa. Methods included who received measurements between 2003 and 2017 in medical center Taiwan. Logistic regression modeling was used to assess association PCa age subgroups. further applied C-statistic decision curve analysis compare that PSA. Results identified 626 patients 40836 without The slope > 60-year-old almost 3 times those70-year-old: 5.84 ng/mL) were comparable those observed based on all groups. discrimination 75th percentile better than among aged